Cardiovascular autonomic dysfunction in non-obese diabetic mice

Imagem de Miniatura
Arquivos
art_SOUZA_Cardiovascular_autonomic_dysfunction_in_non_obese_diabetic_mice_2013.PDF (311.39 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
MORAES, Oscar A.
COLUCCI, Juliana A.
MORAES-SILVA, Ivana C.
ANGELIS, Katia De
CASARINI, Dulce E.
Citação
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v.177, n.2, p.143-147, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
It is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). In the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. In conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction.
Palavras-chave
Diabetes mellitus, Autonomic nervous system, Baroreflex, Mice, Inbred NOD
URI
https://observatorio.fm.usp.br/handle/OPI/4539
Referências
  1. Abd El Dayem SM, 2011, ANADOLU KARDIYOL DER, V11, P224, DOI 10.5152/akd.2011.061
  2. Billman GE, 2009, AM J PHYSIOL-HEART C, V297, pH1171, DOI 10.1152/ajpheart.00534.2009
  3. CHANG KSK, 1986, J MOL CELL CARDIOL, V18, P617, DOI 10.1016/S0022-2828(86)80969-5
  4. Colucci JA, 2011, J RENIN-ANGIO-ALDO S, V12, P15, DOI 10.1177/1470320310375456
  5. Dall'Ago P, 2002, BRAZ J MED BIOL RES, V35, P843, DOI 10.1590/S0100-879X2002000700013
  6. De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
  7. De Angelis K, 2004, J APPL PHYSIOL, V96, P2174, DOI 10.1152/japplphysiol.00870.2003
  8. Fazan R, 1999, J HYPERTENS, V17, P489, DOI 10.1097/00004872-199917040-00006
  9. Flecknell P.A., 1992, LAB ANIM, V26, P241
  10. Fu WX, 2012, NAT IMMUNOL, V13, P361, DOI 10.1038/ni.2233
  11. Gross V, 2008, AUTON NEUROSCI-BASIC, V138, P108, DOI 10.1016/j.autneu.2007.11.006
  12. Guzzetti S, 2005, CIRCULATION, V112, P465, DOI 10.1161/CIRCULATIONAHA.104.518449
  13. Heeren MV, 2009, MATURITAS, V62, P200, DOI 10.1016/j.maturitas.2008.12.011
  14. Hong LZ, 2012, PHYSIOL RES, V61, P443
  15. Jorge L, 2012, EXP DIABETES RES, DOI 10.1155/2012/108680
  16. Kodama S, 2003, SCIENCE, V302, P1223, DOI 10.1126/science.1088949
  17. La Rovere MT, 1998, LANCET, V351, P478
  18. MAEDA CY, 1995, HYPERTENSION, V26, P1100
  19. Makino S, 1980, Jikken Dobutsu, V29, P1
  20. Camm AJ, 1996, EUR HEART J, V17, P354
  21. Marco Giovana Seno Di, 2008, Int J Biochem Cell Biol, V40, P747, DOI 10.1016/j.biocel.2007.10.016
  22. Maser RE, 2003, DIABETES CARE, V26, P1895, DOI 10.2337/diacare.26.6.1895
  23. Mostarda C, 2009, AUTON NEUROSCI-BASIC, V145, P11, DOI 10.1016/j.autneu.2008.10.010
  24. Porta A, 2007, AM J PHYSIOL-HEART C, V293, pH702, DOI 10.1152/ajpheart.00006.2007
  25. Schaan BD, 1997, BRAZ J MED BIOL RES, V30, P1081
  26. Schmidt RE, 2003, AM J PATHOL, V163, P2077, DOI 10.1016/S0002-9440(10)63565-1
  27. Schmidt RE, 2002, INT REV NEUROBIOL, V50, P257
  28. Schumer M.P., 1998, DIABETES SPECTRUM, V11, P227
  29. Soares PPDA, 2004, AUTON NEUROSCI-BASIC, V113, P24, DOI 10.1016/j.autneu.2004.05.002
  30. Vinik AI, 2007, CIRCULATION, V115, P387, DOI 10.1161/CIRCULATIONAHA.106.634949
  31. WEGNER JA, 1987, MED SCI SPORT EXER, V19, P497
  32. Wichi R, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-14
  33. Zamo FS, 2010, CLINICS, V65, P85, DOI 10.1590/S1807-59322010000100013
  34. Zimmet PZ, 1997, J DIABETES COMPLICAT, V11, P60, DOI 10.1016/S1056-8727(96)00090-6

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/59
Artigos e Materiais de Revistas Científicas - ODS/03