Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/46101| Title: | Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease |
| Authors: | FRADE, Virginia Paula; MOREIRA, Carlos Henrique Valente; SABINO, Ester Cerdeira; BEDOR, Danilo Cesar Galindo; GHILARD, Fabio de Rose; OLIVEIRA, Claudia Di Lorenzo; SANCHES, Cristina |
| Citation: | REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.64, article ID e4, 5p, 2022 |
| Abstract: | The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective cohort study with eight patients diagnosed with Chagas disease during the beginning of BZD treatment up to the 60th day. On the 15th day of treatment, a blood sampling was collected and analyzed. A one-compartment PK model was developed using Pmetrics. Patients with an average age of 50.3 (SD: 6.2) years old, 6 female patients and 2 males, 70.2 kg (14.2), receiving a 5 mg/Kg/day dose were included. PK parameters estimated for CL, V and Ka were 6.27 L/h, 38.97 L and 1.66 h-1, respectively. This is the first study to establish a population pharmacokinetic modeling of BZD in Brazilian patients with chronic Chagas disease. Therefore, further studies are needed to obtain the complete characterization of BZD pharmacokinetics. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/46 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| art_FRADE_Population_pharmacokinetic_modeling_of_benznidazole_in_Brazilian_patients_2022.PDF | publishedVersion (English) | 251.76 kB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.