Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/4614
Title: | Antioxidant Activity of Resveratrol Analogs |
Authors: | CALIL, Natalia Oliveira; CARVALHO, Gustavo Senra Goncalves de; FRANCO, Danielle Cristina Zimmermann; SILVA, Adilson David da; RAPOSO, Nadia Rezende Barbosa |
Citation: | LETTERS IN DRUG DESIGN & DISCOVERY, v.9, n.1, p.8-11, 2012 |
Abstract: | This study evaluated the antioxidant activity of five resveratrol analogs by relating the activity of the molecule with its chemical structure. The five resveratrol analogs were synthesized and the antioxidant activity was evaluated using the DPPH method. The resveratrol was used as the reference standard. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The antioxidant activity of resveratrol analogs was considered statistically different, with the analog A which showed activity superior to the others. The five analogs presented lower antioxidant activity than the reference standard (p <0.001). According to the findings, hydroxylation was the molecular modification that gave the best evaluated antioxidant activity result. Resveratrol analogs may have an important antioxidative activity, but with the one with the higher IC50 was presented by the natural compound. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/27 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_RAPOSO_Antioxidant_Activity_of_Resveratrol_Analogs_2012.PDF Restricted Access | publishedVersion (English) | 83.65 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.