Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients

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Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FUTURE MEDICINE LTD
Autores
NASCIMENTO, Larissa Vilela
MOREIRA, Dalmo Antonio Ribeiro
CERUTTI, Virginia Braga
THUROW, Helena Strelow
BASTOS, Gisele Medeiros
FERREIRA, Eric Batista
HIRATA, Rosario Dominguez Crespo
HIRATA, Mario Hiroyuki
Citação
EPIGENOMICS, v.14, n.14, p.851-864, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aim: This study investigated the influence of antidepressant drugs on methylation status of KCNE1, KCNH2 and SCN5A promoters and ECG parameters in adult psychiatric patients. Materials & methods: Electrocardiographic evaluation (24 h) and blood samples were obtained from 34 psychiatric patients before and after 30 days of antidepressant therapy. Methylation of promoter CpG sites of KCNE1, KCNH2 and SCN5A was analyzed by pyrosequencing. Results: Three CpG and four CpG sites of KCNE1 and SCN5A, respectively, had increased % methylation after treatment. Principal component analysis showed correlations of the methylation status with electrocardiographic variables, antidepressant doses and patient age. Conclusion: Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients.
Palavras-chave
antidepressant drugs, cardiac arrhythmias, DNA methylation, pharmacoepigenetics, pyrosequencing
URI
https://observatorio.fm.usp.br/handle/OPI/48553
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/23