Sex differences in gene regulatory networks during mid-gestational brain development

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art_TOLEDO_Sex_differences_in_gene_regulatory_networks_during_midgestational_2022.PDF (2.65 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
FELTRIN, Arthur Sant'Anna
BARBOSA, Andre Rocha
TAHIRA, Ana Carolina
Citação
FRONTIERS IN HUMAN NEUROSCIENCE, v.16, article ID 955607, 21p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Neurodevetopmental disorders differ considerably between males and females, and fetal brain development is one of the most critical periods to determine risk for these disorders. Transcriptomic studies comparing male and female fetal brain have demonstrated that the highest difference in gene expression occurs in sex chromosomes, but several autossomal genes also demonstrate a slight difference that has not been yet explored. In order to investigate biological pathways underlying fetal brain sex differences, we applied medicine network principles using integrative methods such as co-expression networks (CEMiTool) and regulatory networks (netZoo). The pattern of gene expression from genes in the same pathway tend to reflect biologically relevant phenomena. In this study, network analysis of fetal brain expression reveals regulatory differences between males and females. Integrating two different bioinformatics tools, our results suggest that biological processes such as cell cycle, cell differentiation, energy metabolism and extracellular matrix organization are consistently sex-biased. MSET analysis demonstrates that these differences are relevant to neurodevelopmental disorders, including autism.
Palavras-chave
neurodevelopmental disorders, sex differences, fetal brain development, gene regulatory networks, systems biology, autism spectrum disorder (ASD)
URI
https://observatorio.fm.usp.br/handle/OPI/49354
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/23