Title: | Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder |
Authors: | BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kuersat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYDIN, Memduha; AYHAN, Yavuz; TATEBAYASHI, Yoshitaka; TEH, Wen Lin; BECERRA-PALARS, Claudia; TONDO, Leonardo; TORRENT, Carla; DESAI, Pratikkumar; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VIETA, Eduard; JANNO, Sven; VISWANATH, Biju; YOLDI-NEGRETE, Maria; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; BEHERE, Aniruddh P.; ZGUEB, Yosra; DODD, Seetal; WHYBROW, Peter C.; BEHERE, Prakash B.; BELETE, Habte; JOHNSEN, Simon; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; ETAIN, Bruno; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; KAPCZINSKI, Flavio; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. W.; CHIESA, Silvia; FAGIOLINI, Andrea; CROWE, Marie; KARAKATSOULIS, Gregory N.; CUOMO, Alessandro; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; MOSCA, Enrica; FRYE, Mark A.; GEOFFROY, Pierre A.; GITLIN, Michael J.; GONZALEZ-PINTO, Ana.; KARDELL, Mathias; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; MOZZHEGOROV, Anton A.; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; MUNOZ, Rodrigo; ISOMETSA, Erkki T.; IVKOVIC, Maja; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; RATTA-APHA, Woraphat; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; MYTHRI, Starlin V.; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; RATZENHOFER, Michaela; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; NACEF, Fethi; MARTINI, Julia; MARTINY, Klaus; REDAHAN, Maria; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; MIKOLAS, Pavol; MOK, Yee Ming; MONTEITH, Scott; NADELLA, Ravi K.; MOORTHY, Muthukumaran; REDDY, M. S.; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; BAETHGE, Christopher; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; REIF, Andreas; PETITE, Joanne; PETZOLD, Johannes; PFENNIG, Andrea; RUIZ, Yolanda Pica; PINNA, Marco; POMPILI, Maurizio; BAUER, Rita; PORTER, Richard J.; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; BAUNE, Bernhard T.; RAMESAR, Raj; RASGON, Natalie; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; DALLASPEZIA, Sara; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SMITH, Daniel; SMITH, Jose; STACKHOUSE, Jr Paul W.; BALABAN, Ceylan; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; ZOMPO, Maria Del; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J. |
Citation: | INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, v.11, n.1, article ID 22, 9p, 2023 |
Abstract: | BackgroundSunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.MethodsData for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P <= 0.001.ResultsThe 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.ConclusionUVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Departamento de Psiquiatria - FM/MPS Artigos e Materiais de Revistas Científicas - LIM/21 LIM/21 - Laboratório de Neuroimagem em Psiquiatria |
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