Glioneuronal and Neuronal Tumors: Who? When? Where? An Update Based on the 2021 World Health Organization Classification

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article
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2023
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AMERICAN SOCIETY OF NEURORADIOLOGY
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NEUROGRAPHICS, v.13, n.1, 2023
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Resumo
Neuronal and glioneuronal tumors usually have a benign course and may have typical imaging characteristics, allowing their diagnosis based on MR imaging findings. The most common lesions are dysembryoplastic neuroepithelial tumors and gangliogliomas, which have typical imaging characteristics. The fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System, recently published in 2021, places greater emphasis on molecular markers to classify tumors of the CNS, leading to extensive changes in the classification of tumors, including neuronal and glioneuronal tumors. The 2021 revision included 3 new tumors types: multinodular and vacuolating neuronal tumor, diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (a provisional type), and myxoid glioneuronal tumor. Following these recent changes in the World Health Organization classification, we aimed to review the main imaging features of these lesions in relation to their histopathologic and molecular features. Learning Objectives: To list the neuronal and glioneuronal tumors; recognize the main imaging findings and histologic characteristics of neuronal and glioneuronal tumors; know the typical location of each neuronal and glioneuronal tumor; and become familiar with the main molecular alterations of neuronal and glioneuronal tumors to better understand their behavior
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Referências
  1. Louis DN, Perry A, Reifenberger G, Et al., The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary, Acta Neuropathol, 131, pp. 803-820, (2016)
  2. Louis DN, Perry A, Wesseling P, Et al., The 2021 WHO Classification of Tumors of the Central Nervous System: a summary, Neuro Oncol, 23, pp. 1231-1251, (2021)
  3. Louis DN, Wesseling P, Paulus W, Et al., cIMPACT-NOW update 1: not otherwise specified (NOS) and not elsewhere classified (NEC), Acta Neuropathol, 135, pp. 481-484, (2018)
  4. Louis DN, Giannini C, Capper D, Et al., cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant, Acta Neuropathol, 135, pp. 639-642, (2018)
  5. Brat DJ, Aldape K, Colman H, Et al., cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV, Acta Neuropathol, 136, pp. 805-810, (2018)
  6. Ellison DW, Hawkins C, Jones DTW, Et al., cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF V600E mutation, Acta Neuropathol, 137, pp. 683-687, (2019)
  7. Brat DJ, Aldape K, Colman H, Et al., cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas, Acta Neuropathol, 139, pp. 603-608, (2020)
  8. Louis DN, Wesseling P, Aldape K, Et al., cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading, Brain Pathol, 30, pp. 844-856, (2020)
  9. Ellison DW, Aldape KD, Capper D, Et al., cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors, Brain Pathol, 30, pp. 863-866, (2020)
  10. Gatto L, Franceschi E, Di Nunno V, Et al., Glioneuronal tumors: clinicopathological findings and treatment options, Future Neurology, 15, 3, (2020)
  11. Koeller KK, Henry JM., From the archives of the AFIP superficial gliomas: radiologic-pathologic correlation, Radiographics, 21, pp. 1533-1556, (2001)
  12. Dudley RW, Torok MR, Gallegos DR, Et al., Pediatric low grade ganglioglioma/gangliocytoma: epidemiology, treatments, and outcome analysis on 348 children from the SEER database, Neurosurgery, 76, pp. 313-320, (2015)
  13. Sakata K, Fujimori K, Komaki S, Et al., Pituitary gangliocytoma producing TSH and TRH: a review of “gangliocytomas of the sellar region, J Clin Endocrinol Metab, 105, pp. 3109-3121, (2020)
  14. Altman NR., MR and CT characteristics of gangliocytoma: a rare cause of epilepsy in children, AJNR Am J Neuroradiol, 9, pp. 917-921, (1988)
  15. Li Y, Guo J, Wei H, Et al., The surgical resection of dysplastic cerebellar gangliocytoma assisted by intraoperative sonography: illustrative case, J Neurosurg Case Lessons, 2, pp. 12-18, (2021)
  16. Tan C, McLendon R., Histological approach to neuronal and mixed neuronal-glial tumors of the central nervous system, Glioma, 1, (2018)
  17. Ma J, Jia G, Chen S, Et al., Clinical perspective on dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease), World Neurosurg, 122, pp. 16-23, (2019)
  18. Smith AB, Smirniotopoulos JG, Horkanyne-Szakaly I., From the radiologic pathology archives: Intraventricular neoplasms: radiologic-pathologic correlation, Radiographics, 33, pp. 21-43, (2013)
  19. Lee SJ, Bui TT, Chen CHJ, Et al., Central neurocytoma: a review of clinical management and histopathologic features, Brain Tumor Res Treat, 4, pp. 49-57, (2016)
  20. Demir MK, Yapicier O, Yilmaz B, Et al., Magnetic resonance imaging findings of mixed neuronal-glial tumors with pathologic correlation: a review, Acta Neurol Belg, 118, pp. 379-386, (2018)
  21. Yang GF, Wu SY, Zhang LJ, Et al., Imaging findings of extraventricular neurocytoma: report of 3 cases and review of the literature, AJNR Am J Neuroradiol, 30, pp. 581-585, (2009)
  22. Wolf A, Alghefari H, Krivosheya D, Et al., Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition—case report, J Neurosurg, 125, pp. 57-61, (2016)
  23. Patel N, Fallah A, Provias J, Jha NK., Cerebellar liponeurocytoma, Can J Surg, 52, 4, pp. E117-E119, (2009)
  24. Cai J, Li W, Du J, Et al., Supratentorial intracerebral cerebellar liponeurocytoma: a case report and literature review, Medicine (Baltimore), 97, (2018)
  25. Elia G, Lorenzo U, Annarita G, Et al., Cerebellar liponeurocytoma presenting with fatal tumor hemorrhage, Neurosurgery Cases and Reviews, 210, (2019)
  26. Campos AR, Clusmann H, Von Lehe M, Et al., Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology, Neuroradiology, 51, pp. 433-443, (2009)
  27. Raz E, Kapilamoorthy TR, Gupta AK, Et al., Case 186: dysembrioplastic neuroepithelial tumor, Radiology, 265, pp. 317-320, (2012)
  28. Onishi S, Amatya VJ, Kolakshyapati M, Et al., T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor, Eur J Radiol, 126, (2020)
  29. Suh YL., Dysembryoplastic neuroepithelial tumors, J Pathol Transl Med, 49, pp. 438-449, (2015)
  30. Daumas-Duport C., Dysembryoplastic neuroepithelial tumours, Brain Pathol, 3, pp. 283-295, (1993)
  31. Lucas CH, Gupta R, Doo P, Et al., Correction to: comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor, Acta Neuropathol Commun, 8, pp. 1-17, (2020)
  32. Pekmezci M, Villanueva-Meyer JE, Goode B, Et al., The genetic landscape of ganglioglioma, Acta Neuropathol Commun, 6, (2018)
  33. Gessi M, Mu hlen A, Zur Hammes J, Et al., Genome-wide DNA copy number analysis of desmoplastic infantile astrocytomas and desmoplastic infantile gangliogliomas, J Neuropathol Exp Neurol, 72, pp. 807-815, (2013)
  34. Trehan G, Bruge H, Vinchon M, Et al., MR imaging in the diagnosis of desmoplastic infantile tumor: retrospective study of six cases, AJNR Am J Neuroradiol, 25, pp. 1028-1033, (2004)
  35. Bader A, Heran M, Dunham C, Et al., Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience, J Neurosurg Pediatr, 16, pp. 119-125, (2015)
  36. Wang AC, Jones DTW, Abecassis IJ, Et al., Desmoplastic infantile ganglioglioma/astrocytoma (DIG/DIA) are distinct entities with frequent BRAFV600 mutations, Mol Cancer Res, 16, pp. 1491-1498, (2018)
  37. Blessing MM, Blackburn PR, Balcom JR, Et al., Novel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy, Acta Neuropathol Commun, 6, (2018)
  38. Dougherty MJ, Santi M, Brose MS, Et al., Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas, Neuro Oncol, 12, pp. 621-630, (2010)
  39. Prabowo AS, Iyer AM, Veersema TJ, Et al., BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors, Brain Pathol, 24, pp. 52-66, (2014)
  40. Myung JK, Byeon SJ, Kim B, Et al., Papillary glioneuronal tumors: a review of clinicopathologic and molecular genetic studies, Am J Surg Pathol, 35, pp. 1794-1805, (2011)
  41. Yadav N, Rao S, Saini J, Et al., Papillary glioneuronal tumors: a radiopathologic correlation, Eur J Radiol, 97, pp. 44-52, (2017)
  42. Wilson CP, Chakraborty AR, Pelargos PE, Et al., Rosette-forming glioneuronal tumor: an illustrative case and a systematic review, Neurooncology Adv, 2, (2020)
  43. Shah MN, Leonard JR, Perry A., Rosette-forming glioneuronal tumors of the posterior fossa: report of 6 cases, J Neurosurg Pediatr, 5, pp. 98-103, (2010)
  44. Pekmezci M, Stevers M, Phillips JJ, Et al., Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway, Acta Neuropathol, 135, pp. 485-488, (2018)
  45. Nunes RH, Hsu CC, Da Rocha AJ, Et al., Multinodular and vacuolating neuronal tumor of the cerebrum: a new “leave me alone” lesion with a characteristic imaging pattern, AJNR Am J Neuroradiol, 38, pp. 1899-1904, (2017)
  46. Huse JT, Edgar M, Halliday J, Et al., Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion, Brain Pathol, 23, pp. 515-524, (2013)
  47. Lecler A, Bailleux J, Carsin B, Et al., Multinodular and vacuolating posterior fossa lesions of unknown significance, AJNR Am J Neuroradiol, 40, pp. 1689-1694, (2019)
  48. Bodi I, Curran O, Selway R, Et al., Two cases of multinodular and vacuolating neuronal tumour, Acta Neuropathol Commun, 2, pp. 1-10, (2014)
  49. Lakhani DA, Mankad K, Chhabda S, Et al., Diffuse leptomeningeal glioneuronal tumor of childhood, AJNR Am J Neuroradiol, 41, pp. 2155-2159, (2020)
  50. Deng MY, Sill M, Chiang J, Et al., Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features, Acta Neuropathol, 136, pp. 239-253, (2018)
  51. Deng MY, Sill M, Sturm D, Et al., Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC): a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14, Neuropathol Appl Neurobiol, 46, pp. 422-430, (2020)
  52. Pickles JC, Mankad K, Aizpurua M, Et al., A case series of diffuse glioneuronal tumours with oligodendroglioma-like features and nuclear clusters (DGONC), Neuropathol Appl Neurobiol, 47, pp. 464-467, (2021)
  53. Solomon DA, Korshunov A, Sill M, Et al., Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile, Acta Neuropathol, 136, pp. 339-343, (2018)
  54. Narvaez E de O, Inada BS, de Almeida PR, Et al., Myxoid glioneuronal tumour: report of three cases of a new tumour in a typical location and review of literature, BJR Case Rep, 7, (2021)
  55. Lucas CH, Villanueva-Meyer JE, Whipple N, Et al., Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features, Brain Pathol, 30, pp. 479-494, (2020)
  56. Broen MP, Smits M, Wijnenga MM, Et al., The T2-FLAIR mismatch sign as an imaging marker for non-enhancing IDH-mutant, 1p/19q-intact lower-grade glioma: a validation study, Neuro Oncol, 20, pp. 1393-1399, (2018)