Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study

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Citações na Scopus
1
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
TROTTA, Giulia
RODRIGUEZ, Victoria
QUATTRONE, Diego
SPINAZZOLA, Edoardo
TRIPOLI, Giada
GAYER-ANDERSON, Charlotte
FREEMAN, Tom P.
JONGSMA, Hannah E.
SIDELI, Lucia
AAS, Monica
Citação
PSYCHOLOGICAL MEDICINE, v.53, n.15, p.7375-7384, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. MethodsData were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. ResultsThe association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. ConclusionsHarmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.
Palavras-chave
Cannabis use, childhood experience, mediation, psychotic disorders, trauma
URI
https://observatorio.fm.usp.br/handle/OPI/58974
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR