Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study
Carregando...
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
TRZESNIAK, C.
MCGUIRE, P. K.
MURRAY, R. M.
HALLAK, J. E. C.
Citação
PSYCHOLOGICAL MEDICINE, v.42, n.12, p.2523-2534, 2012
Resumo
Background. Neurodevelopmental alterations have been described inconsistently in psychosis probably because of lack of standardization among studies. The aim of this study was to conduct the first longitudinal and population-based magnetic resonance imaging (MRI) evaluation of the presence and size of the cavum septum pellucidum (CSP) and adhesio interthalamica (AI) in a large sample of patients with first-episode psychosis (FEP). Method. FEP patients (n=122) were subdivided into schizophrenia (n=62), mood disorders (n=46) and other psychosis (n=14) groups and compared to 94 healthy next-door neighbour controls. After 13 months, 80 FEP patients and 52 controls underwent a second MRI examination. Results. We found significant reductions in the AI length in schizophrenia FEP in comparison with the mood disorders and control subgroups (longer length) at the baseline assessment, and no differences in any measure of the CSP. By contrast, there was a diagnosis x time interaction for the CSP length, with a more prominent increase for this measure in the psychosis group. There was an involution of the AI length over time for all groups but no diagnosis x time interaction. Conclusions. Our findings suggest that the CSP per se may not be linked to the neurobiology of emerging psychotic disorders, although it might be related to the progression of the disease. However, the fact that the AI length was shown to be shorter at the onset of the disorder supports the neurodevelopmental model of schizophrenia and indicates that an alteration in this grey matter junction may be a risk factor for developing psychosis.
Palavras-chave
Adhesio interthalamica, cavum septum pellucidum, first-episode psychosis, magnetic resonance imaging, schizophrenia
Referências
- ALLEN LS, 1991, J COMP NEUROL, V312, P97, DOI 10.1002/cne.903120108
- ANDREASEN NC, 1994, SCIENCE, V266, P294, DOI 10.1126/science.7939669
- ANNETT M, 1970, BRIT J PSYCHOL, V61, P303
- APA, 1994, DIAGN STAT MAN MENT
- Ashburner J, 2000, NEUROIMAGE, V11, P805, DOI 10.1006/nimg.2000.0582
- Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
- BEBBINGTON P, 1995, INT J METHOD PSYCH, V5, P11
- Broome MR, 2005, SCHIZOPHR RES, V79, P23, DOI 10.1016/j.schres.2005.02.007
- Cohen BM, 1998, PSYCHOPHARMACOLOGY, V135, P37, DOI 10.1007/s002130050483
- Crippa JAD, 2006, EUR PSYCHIAT, V21, P291, DOI 10.1016/j.eurpsy.2005.09.010
- First M.B., 1995, STRUCTURED CLIN INTE
- HIRAYASU Y, 1992, BRAIN RES, V577, P36, DOI 10.1016/0006-8993(92)90534-G
- Ho BC, 2011, ARCH GEN PSYCHIAT, V68, P128, DOI 10.1001/archgenpsychiatry.2010.199
- Kasai K, 2004, SCHIZOPHR RES, V71, P65, DOI 10.1016/j.schres.2003.12.010
- KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261
- Keshavan Matcheri S, 2002, CNS Spectr, V7, P155
- Kwon JS, 1998, AM J PSYCHIAT, V155, P509
- LEVIEL V, 1981, BRAIN RES, V223, P257, DOI 10.1016/0006-8993(81)91140-9
- Littell R. C., 1996, SAS MIXED MODELS
- McEvoy PM, 2011, AUST NZ J PSYCHIAT, V45, P957, DOI 10.3109/00048674.2011.624083
- MCGLONE J, 1980, BEHAV BRAIN SCI, V3, P215
- Meisenzahl EM, 2002, PSYCHIAT RES-NEUROIM, V115, P127, DOI 10.1016/S0925-4927(02)00044-6
- Menezes PR, 2007, BRIT J PSYCHIAT, V191, pS102, DOI 10.1192/bjp.191.51.s102
- MURRAY RM, 1987, BRIT MED J, V295, P681
- Nopoulos P, 1997, BIOL PSYCHIAT, V41, P1102, DOI 10.1016/S0006-3223(96)00209-0
- Nopoulos PC, 2001, SCHIZOPHR RES, V48, P177, DOI 10.1016/S0920-9964(00)00067-0
- RAKIC P, 1968, J COMP NEUROL, V132, P45, DOI 10.1002/cne.901320103
- ROMO R, 1984, BRAIN RES, V308, P43, DOI 10.1016/0006-8993(84)90915-6
- ROSALES RK, 1968, J NEUROPATH EXP NEUR, V27, P166
- SAMRA KA, 1968, RADIOLOGY, V91, P1124
- Schaufelberger MS, 2010, PSYCHOL MED, V41, P1677
- Schaufelberger MS, 2007, BRIT J PSYCHIAT, V191, pS117, DOI 10.1192/bjp.191.51.s117
- SHAW CM, 1969, BRAIN, V92, P213, DOI 10.1093/brain/92.1.213
- Snyder PJ, 1998, J NEUROIMAGING, V8, P159
- Suzuki M, 2005, BRAIN, V128, P2109, DOI 10.1093/brain/awh554
- Takahashi T, 2008, PSYCHIAT RES-NEUROIM, V164, P90, DOI 10.1016/j.pscychresns.2008.03.001
- Takahashi T, 2007, PROG NEURO-PSYCHOPH, V31, P1235, DOI 10.1016/j.pnpbp.2007.04.019
- Takahashi T, 2008, PROG NEURO-PSYCHOPH, V32, P1708, DOI 10.1016/j.pnpbp.2008.07.007
- Takahashi T, 2008, SCHIZOPHR RES, V105, P236, DOI 10.1016/j.schres.2008.06.021
- Tominaga M, 2009, SOC PSYCH PSYCH EPID, V44, P777, DOI 10.1007/s00127-009-0499-1
- Trzesniak C, 2011, PROG NEURO-PSYCHOPH, V35, P877, DOI 10.1016/j.pnpbp.2010.12.024
- Trzesniak C, 2011, SCHIZOPHR RES, V125, P1, DOI 10.1016/j.schres.2010.09.016
- Woods SW, 2003, J CLIN PSYCHIAT, V64, P663
- WRIGHT P, 1995, AM J PSYCHIAT, V152, P1714
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/39
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/39