Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus
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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER DOYMA SL
Citação
REVISTA PORTUGUESA DE CARDIOLOGIA, v.33, n.11, p.685-690, 2014
Resumo
Objective: Due to the chronic inflammation associated with systemic lupus erythematosus (SLE), patients develop premature atherosclerosis and the disease is a risk factor for acute myocardial infarction. The best interventional treatment for acute coronary syndrome (ACS) in these patients is unclear. The objective of this study is to describe the baseline characteristics, clinical manifestations, treatment and in-hospital outcome of patients with SLE and ACS. Methods: Eleven SLE patients with ACS were analyzed retrospectively between 2004 and 2011. The following data were obtained: age, gender, clinical and electrocardiographic characteristics, Killip class, risk factors for ACS, myocardial necrosis markers (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), drugs used during hospital stay, treatment (medical, percutaneous or surgical) and in-hospital outcome. The statistical analysis is presented in percentages and absolute values. Results: Ten of the patients (91%) were women. The median age was 47 years. Typical precordial pain was present in 91%. Around 73% had positive erythrocyte sedimentation rate. The vessel most often affected was the anterior descending artery, in 73%. One patient underwent coronary artery bypass grafting, seven underwent percutaneous coronary intervention with bare-metal stents and three were treated medically. In-hospital mortality was 18%. Conclusions: Despite the small number of patients, our findings were similar to those in the literature, showing coronary artery disease in young people with SLE due to premature atherosclerosis and a high mortality rate.
Palavras-chave
Systemic lupus erythematosus, Acute coronary syndromes, Inflammation
Referências
- Bozbuga N, 2004, J CARDIAC SURG, V19, P471, DOI 10.1111/j.0886-0440.2004.05005.x
- de Godoy Moacir Fernandes, 2013, BMC Res Notes, V6, P171, DOI 10.1186/1756-0500-6-171
- Escarcega RO, 2006, AUTOIMMUN REV, V6, P48, DOI 10.1016/j.autrev.2006.07.001
- Galindo M, 2005, NAT CLIN PRACT RHEUM, V1, P55, DOI 10.1038/ncprheum0037
- Hak AE, 2009, ARTHRIT CARE RES, V61, P1396, DOI 10.1002/art.24537
- Haque S, 2010, J RHEUMATOL, V37, P322, DOI 10.3899/jrheum.090306
- Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928
- Karp I, 2008, ARTHRIT RHEUM-ARTHR, V59, P169, DOI 10.1002/art.23352
- Kiani AN, 2012, J RHEUMATOL, V39, P2286, DOI 10.3899/jrheum.120197
- Lee CH, 2008, INT J CARDIOL, V126, P430, DOI 10.1016/j.ijcard.2007.01.117
- Mattu A, 2005, AM J EMERG MED, V23, P696, DOI 10.1016/j.ajem.2004.12.012
- Miranda CH, 2012, ARQ BRAS CARDIOL, V98, pE66, DOI 10.1590/S0066-782X2012000400014
- Ormseth MJ, 2013, LUPUS, V22, P26, DOI 10.1177/0961203312462756
- Recio-Mayoral A, 2009, EUR HEART J, V30, P1837, DOI 10.1093/eurheartj/ehp205
- Ribeiro AR, 2010, ACTA REUMATOL PORT, V35, P36
- Roldan CA, 2008, HEART, V94, P1089, DOI 10.1136/hrt.2007.132787
- Stojan G, 2013, J CARDIOVASC PHARM, V62, P255, DOI 10.1097/FJC.0b013e31829dd857