Effects of bovine leukemia virus infection on milk neutrophil function and the milk lymphocyte profile

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art_LIBERA_Effects_of_bovine_leukemia_virus_infection_on_milk_2015.PDF (411.88 KB)
Citações na Scopus
42
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
LIBERA, Alice Maria Melville Paiva Della
SOUZA, Fernando Nogueira de
BATISTA, Camila Freitas
SANTOS, Bruna Parapinski
AZEVEDO, Luis Fernando Fernandes de
DINIZ, Soraia Araujo
SILVA, Marcos Xavier
HADDAD, Joao Paulo
BLAGITZ, Maiara Garcia
Citação
VETERINARY RESEARCH, v.46, article ID 2, 8p, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The effects of bovine leukemia virus (BLV) on the immune response have been extensively investigated; however, its effects on mammary gland immunity are only speculative. Although BLV has a tropism for B cells, it can affect both adaptive and innate immunities because these systems share many effector mechanisms. This scenario is the basis of this investigation of the effects of BLV on mammary gland immunity, which is largely dependent upon neutrophilic functions. Thus, the present study sought to examine neutrophilic functions and the lymphocyte profile in the milk of naturally BLV-infected cows. The viability of the milk neutrophils and the percentage of milk neutrophils that produced reactive oxygen species (ROS) or phagocytosed Staphylococcus aureus were similar between BLV-infected and BLV-uninfected dairy cows. Furthermore, the expression of CD62L and CD11b by the milk neutrophils and the percentage of milk neutrophils (CH138(+) cells) that were obtained from the udder quarters of the BLV-infected cows were not altered. Conversely, the median fluorescence intensity (MFI) representing intracellular ROS production and the phagocytosis of S. aureus, the expression of CD44 by the milk neutrophils and the percentage of apoptotic B cells were lower in the milk cells from BLV-infected dairy cows, particularly those from animals with persistent lymphocytosis (PL). The lymphocyte subsets were not different among the groups, with the exception of the percentage of CD5-/CD11b(-) B cells, which was higher in the milk cells from BLV-infected cows, particularly those with PL. Thus, the present study provides novel insight into the implications of BLV infection for mammary gland immunity.
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URI
https://observatorio.fm.usp.br/handle/OPI/9614
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/38