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https://observatorio.fm.usp.br/handle/OPI/1125
Title: | Clinical implication of 14-3-3 epsilon expression in gastric cancer |
Authors: | LEAL, Mariana Ferreira; CALCAGNO, Danielle Queiroz; DEMACHKI, Samia; ASSUMPCAO, Paulo Pimentel; CHAMMAS, Roger; BURBANO, Rommel Rodriguez; SMITH, Marilia de Arruda Cardoso |
Citation: | WORLD JOURNAL OF GASTROENTEROLOGY, v.18, n.13, p.1531-1537, 2012 |
Abstract: | AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3 epsilon in gastric carcinogenesis. METHODS: 14-3-3 epsilon protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples. RESULTS: Authors observed a significant reduction of 14-3-3 epsilon protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue, Reduced levels of 14-3-3 epsilon were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3 epsilon may have a role in gastric carcinogenesis process. CONCLUSION: Our results reveal that the reduced 14-3-3 epsilon expression in GC and investigation of 14-3-3 epsilon interaction partners may help to elucidate the carcinogenesis process. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - LIM/24 |
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File | Description | Size | Format | |
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art_CHAMMAS_Clinical_implication_of_14_3_3_epsilon_expression_2012.PDF | publishedVersion (English) | 863.46 kB | Adobe PDF | View/Open |
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