Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/2116
Title: | Cannabis use, cognition and brain structure in first-episode psychosis |
Authors: | CUNHA, Paulo Jannuzzi; ROSA, Pedro Gomes P.; AYRES, Adriana de Mello; DURAN, Fabio L. S.; SANTOS, Luciana C.; SCAZUFCA, Marcia; MENEZES, Paulo R.; SANTOS, Bernardo dos; MURRAY, Robin M.; CRIPPA, Jose Alexandre S.; BUSATTO, Geraldo F.; SCHAUFELBERGER, Maristela S. |
Citation: | SCHIZOPHRENIA RESEARCH, v.147, n.2-3, p.209-215, 2013 |
Abstract: | Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gray matter and lateral ventricle volumes in 28 patients with first-episode psychosis and a history of Cannabis use, 78 patients without a history of Cannabis use and 80 healthy controls who had not used Cannabis. Cognition was assessed using forward and backwards digit span tests, from the Wechsler Memory Scale-Third Edition (WMS-III) and the Controlled Oral Word Association Test (COWAT). Patients with a history of Cannabis use had less brain abnormalities, characterized by gray matter and lateral ventricle volume preservation, as well as less attentional and executive impairments compared to patients without a history of Cannabis use. Cannabis-using patients who develop psychosis have less neurodevelopmental impairment and better cognitive reserve than other psychotic patients; perhaps reflecting different etiological processes. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/21 Artigos e Materiais de Revistas Científicas - LIM/23 Artigos e Materiais de Revistas Científicas - LIM/39 |
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