Atherosclerosis and Dementia A Cross-Sectional Study With Pathological Analysis of the Carotid Arteries

Imagem de Miniatura
Arquivos
art_SUEMOTO_Atherosclerosis_and_Dementia_A_CrossSectional_Study_With_Pathological_2011.PDF (291.2 KB)
Citações na Scopus
39
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
FREGNI, Felipe
Citação
STROKE, v.42, n.12, p.3614-U440, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and Purpose-Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. Methods-Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n = 112) and control subjects (n = 577). Multivariate logistic regression models were applied. Results-High-grade left internal carotid stenosis (>= 70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P = 0.02). Intima-media thickness was not associated with dementia. Conclusions-The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors. (Stroke. 2011; 42: 3614-3615.)
Palavras-chave
carotid stenosis, dementia, pathology
URI
https://observatorio.fm.usp.br/handle/OPI/22667
Referências
  1. Jorm AF, 2004, INT PSYCHOGERIATR, V16, P275, DOI 10.1017/S1041610204000390
  2. MORRIS JC, 1993, NEUROLOGY, V43, P2412
  3. Johnston SC, 2004, ANN INTERN MED, V140, P237
  4. Grinberg Lea Tenenholz, 2007, Cell and Tissue Banking, V8, P151, DOI 10.1007/s10561-006-9022-z
  5. Romero JR, 2009, STROKE, V40, P1590, DOI 10.1161/STROKEAHA.108.535245
  6. del Sol AI, 2001, STROKE, V32, P1532
  7. Schulte-Altedorneburg G, 2001, STROKE, V32, P1520
  8. VANOIJEN A, 2007, ANN NEUROL, V61, P403

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Carregar mais