First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction

Imagem de Miniatura
Arquivos
art_KOSTIC_Firstyear_profile_of_biomarkers_for_early_detection_of_2019.PDF (1.29 MB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
Citação
PEDIATRIC NEPHROLOGY, v.34, n.6, p.1117-1128, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage. Methods This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-beta 1), retinol-binding protein (RBP), cystatin C (mu CyC), and microalbuminuria (ALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Results All urine biomarkers showed significantly higher values at the first month of life (p <= 0.009), while NGAL (p = 0.005), TGF-beta 1 (p<0.001), and mu ALB (p<0.001) were high since birth compared to controls. Best single biomarker performances were RBP in bilateral hydronephrosis and LUTO subgroups and KIM-1 in unilateral hydronephrosis subgroup. Best biomarker combination results for all subgroups were obtained by matching RBP with TGF-beta 1 or KIM-1 and NGAL with CyC ([AUC] <= 0.934; sensitivity <= 92.4%; specificity <= 92.8%). Conclusions RBP, NGAL, KIM-1, TGF-beta 1, and CyC, alone and especially in combination, are relatively efficient in identifying surgically amenable congenital UTO and could be of practical use in indicating on-time surgery.
Palavras-chave
Congenital urinary tract obstruction, Hydronephrosis, Renal biomarkers, Infants
URI
https://observatorio.fm.usp.br/handle/OPI/32493
Referências
  1. Abitbol CL, 2016, PEDIATR NEPHROL, V31, P2213, DOI 10.1007/s00467-016-3320-x
  2. Anumba DO, 2005, PRENATAL DIAG, V25, P7, DOI 10.1002/pd.1074
  3. BANGSTAD HJ, 1995, PEDIATR NEPHROL, V9, P299, DOI 10.1007/BF02254190
  4. Chevalier RL, 2008, PEDIATR RADIOL, V38, pS35, DOI 10.1007/s00247-007-0585-z
  5. Chevalier RL, 2006, CURR OPIN PEDIATR, V18, P153, DOI 10.1097/01.mop.0000193287.56528.a4
  6. Chevalier Robert L., 2003, Pediatric Nephrology, V18, P576
  7. Chevalier RL, 2010, PEDIATR NEPHROL, V25, P687, DOI 10.1007/s00467-009-1316-5
  8. Decramer S, 2006, NAT MED, V12, P398, DOI 10.1038/nm1384
  9. Decramer S, 2008, CONTRIB NEPHROL, V160, P127, DOI 10.1159/000125956
  10. Dell KM, 2000, UROLOGY, V56, P311, DOI 10.1016/S0090-4295(00)00591-4
  11. El-Sherbiny MT, 2002, J UROLOGY, V168, P1798, DOI 10.1097/01.ju.0000027231.84450.8f
  12. Finney H, 2000, ARCH DIS CHILD, V82, P71, DOI 10.1136/adc.82.1.71
  13. Fiorini F, 2007, J Ultrasound, V10, P161, DOI 10.1016/j.jus.2007.09.001
  14. Freedman AL, 1997, FETAL DIAGN THER, V12, P1, DOI 10.1159/000264415
  15. Gerber C, 2016, J PEDIATR UROL, V12, DOI 10.1016/j.jpurol.2015.10.008
  16. GRIGNON A, 1986, RADIOLOGY, V160, P645, DOI 10.1148/radiology.160.3.3526402
  17. Hossain MA, 2009, AM J NEPHROL, V29, DOI 10.1159/000168486
  18. Huang WY, 2006, KIDNEY INT, V69, P137, DOI 10.1038/sj.ki.5000004
  19. Ismaili K, 2003, AM J OBSTET GYNECOL, V188, P242, DOI 10.1067/mob.2003.81
  20. Jetton JG, 2012, CURR OPIN PEDIATR, V24, P191, DOI 10.1097/MOP.0b013e32834f62d5
  21. Karakus S, 2016, UROLOGY, V87, P185, DOI 10.1016/j.urology.2015.09.007
  22. Klein J, 2011, INT J EXP PATHOL, V92, P168, DOI 10.1111/j.1365-2613.2010.00727.x
  23. Lee RS, 2006, PEDIATRICS, V118, P586, DOI 10.1542/peds.2006-0120
  24. Lee RS, 2009, CURR OPIN UROL, V19, P397, DOI 10.1097/MOU.0b013e32832c90ec
  25. Madsen MG, 2013, DAN MED J, V60
  26. Madsen MG, 2011, J PEDIATR UROL, V7, P105, DOI 10.1016/j.jpurol.2010.12.004
  27. Maisels MJ, 2004, PEDIATRICS, V114, P297
  28. Mandelia A, 2013, PEDIATR NEPHROL, V28, P1991, DOI 10.1007/s00467-013-2506-8
  29. Miklovicova D, 2008, PEDIATR NEPHROL, V23, P937, DOI 10.1007/s00467-007-0741-6
  30. Misseri R, 2004, J SURG RES, V119, P149, DOI 10.1016/j.jss.2004.02.016
  31. Morris RK, 2008, BEST PRACT RES CL OB, V22, P97, DOI 10.1016/j.bpobgyn.2007.08.007
  32. Morris RK, 2013, LANCET, V382, P1496, DOI 10.1016/S0140-6736(13)60992-7
  33. Murer L, 2006, J UROLOGY, V176, P2668, DOI 10.1016/j.juro.2006.08.055
  34. Nguyen HT, 2014, J PEDIATR UROL, V10, P982, DOI 10.1016/j.jpurol.2014.10.002
  35. Nguyen HT, 2010, J PEDIATR UROL, V6, P212, DOI 10.1016/j.jpurol.2010.02.205
  36. Noyan A, 2015, J PEDIATR UROL, V11, DOI 10.1016/j.jpurol.2015.02.021
  37. Olvera-Posada D, 2017, J ENDOUROL, V31, P111, DOI 10.1089/end.2016.0215
  38. Pasala S, 2017, ARCH DIS CHILDHOOD-E, V102, P37, DOI 10.1136/archdischild-2016-311062
  39. PETERS CA, 1995, J UROLOGY, V154, P1874, DOI 10.1016/S0022-5347(01)66815-0
  40. Schwartz GJ, 2009, CLIN J AM SOC NEPHRO, V4, P1832, DOI 10.2215/CJN.01640309
  41. Taha MA, 2007, BJU INT, V99, P899, DOI 10.1111/j.1464-410X.2006.06641.x
  42. TOMLINSON PA, 1994, PEDIATR NEPHROL, V8, P21, DOI 10.1007/BF00868252
  43. Trnka P, 2012, CLIN J AM SOC NEPHRO, V7, P1567, DOI 10.2215/CJN.09640911
  44. Truong LD, 2011, CONTRIB NEPHROL, V169, P311, DOI 10.1159/000314578
  45. Villar J, 2014, LANCET, V384, P857, DOI 10.1016/S0140-6736(14)60932-6
  46. Wasilewska A, 2011, PEDIATR NEPHROL, V26, P579, DOI 10.1007/s00467-011-1773-5
  47. Wuhl E, 2013, CLIN J AM SOC NEPHRO, V8, P67, DOI 10.2215/CJN.03310412

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/36
Carregar mais