Evaluation of the diaphragm muscle remodeling, inflammation, oxidative stress and vascularization in smokers: An autopsy study

Carregando...
Imagem de Miniatura
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2020
Título da Revista
ISSN da Revista
Título do Volume
Editora
CELL PHYSIOL BIOCHEM PRESS GMBH & CO KG
Citação
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v.54, n.4, p.567-576, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background/Aims: Cigarette smoking is a key factor in systemic inflammation and oxidative stress, and it has also been associated with the loss of muscle strength and an elevated risk of pulmonary diseases. Thus, this study aimed to analyze the effects of cigarette smoking on the diaphragm muscle structure of postmortem samples. Methods: Immunohistochemical techniques were used for muscle remodeling (metalloproteinases 2 and 9), inflammation (cyclooxygenase-2), oxidative stress (8-hydroxy-2'-deoxyguanosine), and vascularization (vascular endothelial growth factor). Hematoxylin and eosin stain was used for histopathological analysis and Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of diaphragm muscle remodeling, oxidative stress, inflammation, and vascularization compared to non-smokers. Conclusion: Diaphragm muscle structure may be negatively affected by cigarette smoking. © 2020 The Author(s).
Palavras-chave
Autopsy study, Cigarette smoke, Diaphragm muscle, Histopathological analysis
Referências
  1. Kalra, J, Chaudhary, AK, Prasad, K, Increased production of oxygen free radicals in cigarette smokers (1991) Int J Exp Pathol, 72, pp. 1-7
  2. Morrow, JD, Frei, B, Longmire, AW, Gaziano, JM, Lynch, SM, Shyr, Y, Strauss, WE, Roberts, LJ, Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: smoking as a cause of oxidative damage (1995) N Engl J Med, 332, pp. 1198-1203
  3. Frei, B, Forte, TM, Ames, BN, Cross, CE, Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma: protective effects of ascorbic acid (1991) Biochem J, 277, pp. 133-138
  4. Reznick, AZ, Cross, CE, Hu, ML, Suzuki, YJ, Khwaja, S, Safadi, A, Motchnik, PA, Halliwell, B, Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation (1992) Biochem J, 286, pp. 607-611
  5. Park, EM, Park, YM, Gwak, YS, Oxidative damage in tissues of rats exposed to cigarette smoke (1998) Free Radic Biol Med, 25, pp. 79-86
  6. Valavanidis, A, Vlachogianni, T, Fiotakis, C, 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis (2009) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 27, pp. 120-139
  7. Carmeli, E, Moas, M, Reznick, AZ, Coleman, R, Matrix metalloproteinases and skeletal muscle: a brief review (2004) Muscle Nerve, 29, pp. 191-197
  8. Shen, W, Li, Y, Zhu, J, Schwendener, R, Huard, J, Interaction between macrophages, TGF-β1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury (2008) J Cell Physiol, 214, pp. 405-412
  9. Barreiro, E, Peinado, VI, Galdiz, JB, Ferrer, E, Marin-Corral, J, Sánchez, F, Gea, J, Barberà, JA, ENIGMA in COPD Project: Cigarette smoke-induced oxidative stress: a role in chronic obstructive pulmonary disease skeletal muscle dysfunction (2010) Am J Respir Crit Care Med, 182, pp. 477-488
  10. Petersen, AMW, Magkos, F, Atherton, P, Selby, A, Smith, K, Rennie, MJ, Pedersen, BK, Mittendorfer, B, Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle (2007) Am J Physiol Endocrinol Metab, 293, pp. E843-E848
  11. Nucci, RAB, de Souza, RR, Suemoto, CK, Busse, AL, Maifrino, LBM, Pasqualucci, CA, Anaruma, CA, Jacob-Filho, W, Cigarette Smoking Impairs the Diaphragm Muscle Structure of Patients without Respiratory Pathologies: An Autopsy Study (2019) Cell Physiol Biochem, 53, pp. 648-655
  12. Greising, SM, Mantilla, CB, Gorman, BA, Ermilov, LG, Sieck, GC, Diaphragm muscle sarcopenia in aging mice (2013) Exp Gerontol, 48, pp. 881-887
  13. Greising, SM, Ermilov, LG, Sieck, GC, Mantilla, CB, Ageing and neurotrophic signalling effects on diaphragm neuromuscular function (2015) J Physiol, 593, pp. 431-440
  14. Nucci, RAB, de Souza, RR, Suemoto, CK, Busse, AL, Maifrino, LBM, Anaruma, CA, Pasqualucci, CA, Jacob-Filho, W, Diaphragm muscle structure in the elderly: Findings from an autopsy study (2020) Acta Histochem, p. 151487
  15. Houston, MS, Silverstein, MD, Suman, V, Risk factors for 30-day mortality in elderly patients with lower respiratory tract infection: community-based study (1997) Arch Intern Med, 157, pp. 2190-2195
  16. El-Solh, AA, Sikka, P, Ramadan, F, Davies, J, Etiology of severe pneumonia in the very elderly (2001) Am J Respir Crit Care Med, 163, pp. 645-651
  17. Rom, O, Kaisari, S, Aizenbud, D, Reznick, AZ, Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown (2012) Ann NY Acad Sci, 1259, pp. 47-53
  18. Rom, O, Kaisari, S, Aizenbud, D, Reznick, AZ, The effects of acetaldehyde and acrolein on muscle catabolism in C2 myotubes (2013) Free Radic Biol Med, 65, pp. 190-200
  19. Scott, A, Wang, X, Reid, WD, Increased injury and intramuscular collagen of the diaphragm in COPD: autopsy observations (2006) Eur Respir J, 27, pp. 51-59
  20. Van Ee, CA, Chasse, AL, Myers, BS, Quantifying skeletal muscle properties in cadaveric test specimens: effects of mechanical loading, postmortem time, and freezer storage (2000) J Biomech Eng, 122, pp. 9-14
  21. Gonzalez-Cadavid, NF, Taylor, WE, Yarasheski, K, Sinha-Hikim, I, Ma, K, Ezzat, S, Shen, R, Bhasin, S, Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting (1998) Proc Natl Acad Sci U S A, 95, pp. 14938-14943
  22. Aberle, DR, Adams, AM, Berg, CD, Blac, WC, Clapp, JD, Fagerstrom, RM, Gareen, IF, Sicks, JD, Reduced lung-cancer mortality with low-dose computed tomographic screening (2011) N Engl J Med, 365, pp. 395-409. , National Lung Screening Trial Research Team
  23. Fabricius, P, Løkke, A, Marott, JL, Vestbo, J, Lange, P, Prevalence of COPD in Copenhagen (2011) Respir Med, 105, pp. 410-417
  24. Notara, V, Panagiotakos, DB, Kouroupi, S, Stergiouli, I, Kogias, Y, Stravopodis, P, Pitsavos, C, GREECS Study Investigators, Greece: Smoking determines the 10-year (2004-2014) prognosis in patients with Acute Coronary Syndrome: the GREECS observational study (2015) Tob Induc Dis, 13, p. 38
  25. Lee, TK, Huang, ZS, Ng, SK, Chan, KWA, Wang, YS, Liu, HW, Lee, JJ, Impact of alcohol consumption and cigarette smoking on stroke among the elderly in Taiwan (1995) Stroke, 26, pp. 790-794
  26. Nucci, RAB, Jacob-Filho, W, Busse, AL, Maifrino, LBM, de Souza, RR, Anatomopathological Assessment of the Diaphragm in Formalin-Fixed, Paraffin-Embedded Sections (2018) J Morphol Sci, 35, pp. 173-176
  27. MacCoun, R, Perlmutter, S, Blind analysis: hide results to seek the truth (2015) Nature News, 526, p. 187
  28. Stang, P, Lydick, E, Silberman, C, Kempel, A, Keating, ET, The prevalence of COPD: using smoking rates to estimate disease frequency in the general population (2000) Chest, 117, pp. 354S-359S
  29. Shinton, R, Beevers, G, Meta-analysis of relation between cigarette smoking and stroke (1989) BMJ, 298, pp. 789-794
  30. Critchley, JA, Capewell, S, Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review (2003) JAMA, 290, pp. 86-97
  31. Berlett, BS, Stadtman, ER, Protein oxidation in aging, disease, and oxidative stress (1997) J Biol Chem, 272, pp. 20313-20316
  32. Marin-Corral, J, Fontes, CC, Pascual-Guardia, S, Sanchez, F, Olivan, M, Argiles, JM, Busquets, S, Barreiro, E, Redox balance and carbonylated proteins in limb and heart muscles of cachectic rats (2010) Antioxid Redox Signal, 12, pp. 365-380
  33. Barreiro, E, del Puerto-Nevado, L, Puig-Vilanova, E, Pérez-Rial, S, Sánchez, F, Martínez-Galán, L, Rivera, S, Peces-Barba, G, Cigarette smoke-induced oxidative stress in skeletal muscles of mice (2012) Respir Physiol Neurobiol, 182, pp. 9-17
  34. Lee, J, Taneja, V, Vassallo, R, Cigarette smoking and inflammation: cellular and molecular mechanisms (2012) J Dent Res, 91, pp. 142-149
  35. Castillo, EM, Goodman-Gruen, D, Kritz-Silverstein, D, Morton, DJ, Wingard, DL, Barrett-Connor, E, Sarcopenia in elderly men and women: the Rancho Bernardo study (2003) Am J Prev Med, 25, pp. 226-231
  36. Lee, JS, Auyeung, TW, Kwok, T, Lau, EM, Leung, PC, Woo, J, Associated factors and health impact of sarcopenia in older Chinese men and women: a cross-sectional study (2007) Gerontology, 53, pp. 404-410
  37. Kok, MO, Hoekstra, T, Twisk, JW, The longitudinal relation between smoking and muscle strength in healthy adults (2012) Eur Addict Res, 18, pp. 70-75
  38. Zeiher, AM, Schächinger, V, Minners, J, Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function (1995) Circulation, 92, pp. 1094-1100
  39. Celermajer, DS, Sorensen, KE, Georgakopoulos, D, Bull, C, Thomas, O, Robinson, J, Deanfield, JE, Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults (1993) Circulation, 88, pp. 2149-2255
  40. Lekakis, J, Papamichael, C, Vemmos, C, Nanas, J, Kontoyannis, D, Stamatelopoulos, S, Moulopoulos, S, Effect of acute cigarette smoking on endothelium-dependent brachial artery dilation in healthy individuals (1997) Am J Cardiol, 79, pp. 529-531
  41. Ten, VS, Pinsky, DJ, Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction (2002) Curr Opin Crit Care, 8, pp. 242-250
  42. Kawashima, S, Yokoyama, M, Dysfunction of endothelial nitric oxide synthase and atherosclerosis (2004) Arterioscler Thromb Vasc Biol, 24, pp. 998-1005
  43. Coultas, L, Chawengsaksophak, K, Rossant, J, Endothelial cells and VEGF in vascular development (2005) Nature, 438, p. 937